Recombinant Human Growth Hormone
Recombinant Human Growth Hormone (somatropin) is a purified polypeptide hormone of recombinant DNA origin. It has an amino acid sequence identical to the naturally occurring growth hormone produced by the pituitary gland. It stimulates linear growth, skeletal growth, cell regeneration, and plays an essential role in metabolic processes including protein synthesis and lipid metabolism.
Dosage by Body Weight
Dosages must be highly individualized and determined by a specialist (endocrinologist) based on the patient's body weight, body surface area, and the specific medical condition being treated. It is administered via subcutaneous injection, and injection sites should be rotated daily to prevent lipoatrophy.
- Body Weight
- Below 5 kg
- Dose
- Highly individualized
- Frequency
- Once daily
- Tracking Notes
- Not routinely administered to infants in this weight range unless treating neonatal congenital growth hormone deficiency under strict endocrinology supervision.
- Body Weight
- 5-7 kg
- Dose
- 0.12 mg to 0.24 mg
- Frequency
- Once daily subcutaneous injection
- Tracking Notes
- Based on standard pediatric GHD dosing of approximately 0.024 to 0.034 mg/kg/day. Exact dose must be calculated and monitored by a physician.
- Body Weight
- 8-10 kg
- Dose
- 0.19 mg to 0.34 mg
- Frequency
- Once daily subcutaneous injection
- Tracking Notes
- Doses are adjusted dynamically based on growth velocity, clinical response, and serum insulin-like growth factor 1 (IGF-1) levels.
- Body Weight
- 11-15 kg
- Dose
- 0.26 mg to 0.51 mg
- Frequency
- Once daily subcutaneous injection
- Tracking Notes
- Other indications, such as Turner Syndrome or Noonan Syndrome, may require higher dosing regimens (up to 0.067 mg/kg/day).
- Body Weight
- 16-20 kg
- Dose
- 0.38 mg to 0.68 mg
- Frequency
- Once daily subcutaneous injection
- Tracking Notes
- Rotate injection sites regularly. Dosage must be adjusted as the child grows and progresses through puberty.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | Highly individualized | Once daily | Not routinely administered to infants in this weight range unless treating neonatal congenital growth hormone deficiency under strict endocrinology supervision. |
| 5-7 kg | 0.12 mg to 0.24 mg | Once daily subcutaneous injection | Based on standard pediatric GHD dosing of approximately 0.024 to 0.034 mg/kg/day. Exact dose must be calculated and monitored by a physician. |
| 8-10 kg | 0.19 mg to 0.34 mg | Once daily subcutaneous injection | Doses are adjusted dynamically based on growth velocity, clinical response, and serum insulin-like growth factor 1 (IGF-1) levels. |
| 11-15 kg | 0.26 mg to 0.51 mg | Once daily subcutaneous injection | Other indications, such as Turner Syndrome or Noonan Syndrome, may require higher dosing regimens (up to 0.067 mg/kg/day). |
| 16-20 kg | 0.38 mg to 0.68 mg | Once daily subcutaneous injection | Rotate injection sites regularly. Dosage must be adjusted as the child grows and progresses through puberty. |
Formulation
Purpose
Treatment of pediatric growth hormone deficiency (GHD), Turner syndrome, Prader-Willi syndrome, chronic kidney disease-induced growth failure, small for gestational age (SGA) growth failure, adult growth hormone deficiency, and short bowel syndrome.
Generic Name
SomatropinBranded Drug Names
Recombinant Human Growth Hormone is listed as a generic drug name. Common branded medicines that may contain the same active ingredient include:
Scheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.